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Friday, July 31, 2020 | History

4 edition of Pharmacogenomics in Admixed Populations found in the catalog.

Pharmacogenomics in Admixed Populations

Guilherme Suarez-kurtz

Pharmacogenomics in Admixed Populations

by Guilherme Suarez-kurtz

  • 259 Want to read
  • 20 Currently reading

Published by Landes Bioscience .
Written in English

    Subjects:
  • Medicine / General

  • The Physical Object
    FormatHardcover
    ID Numbers
    Open LibraryOL12320625M
    ISBN 101587063115
    ISBN 109781587063114
    OCLC/WorldCa152793484

    Pharmacogenetic variation (eg, in acetylation, hydrolysis, oxidation, or drug-metabolizing enzymes) can have clinical consequences (see table Examples of Pharmacogenetic Variations).For example, if patients metabolize certain drugs rapidly, they may require higher, more frequent doses to achieve therapeutic concentrations; if patients metabolize certain drugs slowly, they may need lower, less. Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases.5/5(1).

      Pharmacogenomics 1. SIRISHAANNAVARAPU DEPT OF PHARMACOLOGY, KIMS 2. Introduction • Pharmacogenomics deals with the influence of genetic variation on drug response by co-relating gene expression or polymorphism with a drug’s efficacy or toxicity • It intends to identify individuals who are either more likely or less likely to respond to a drug, as well as those who require . defined populations, such as specific ethnicities, that account for variability in pharmacotherapeutic responses. For the purposes of this chapter, the term pharmacogenomics is used more generally to refer to genetic polymorphisms that occur in a patient population—for instance, in an ethnic group—as opposed to individual patients.

    number of adverse drug reactions and increase the effectiveness of drugs. Pharmacogenomics has been characterized as “getting the right dose of the right drug to the right patient at the right time.”2 This brochure is intended to introduce the concept of pharmacogenomics to physicians and other health care providers using a case-based approach.   Pharmacy Resources by Topic Pharmacogenomics Search this Guide Search. Pharmacy Resources by Topic E-Book. Pharmacogenomics by American College of Clinical Pharmacy Staff (Contribution by) Pharmacogenomics in Admixed Populations by Guilherme Suarez-Kurtz ISBN: Publication Date: Author: Genevieve Engle.


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Pharmacogenomics in Admixed Populations by Guilherme Suarez-kurtz Download PDF EPUB FB2

ISBN: OCLC Number: Description: xiii, pages: illustrations ; 24 cm. Contents: The evolution and structure of human genetic diversity / Sergio D.J. Pena --Controlling the effects of population stratification by admixture in pharmacogenetics / Eduardo Tarazona-Santos, Sara Raimondi, and Silvia Fuselli --Admixture in North America / Esteban J.

Parra. Ethnic specificity has become an integral part of research in the overlapping sciences of pharmacogenetics and pharmacogenomics.

Pharmacogenomics in Admixed Populations was conceived to compile pharmacogenetic/-genomic (PGx) Pharmacogenomics in Admixed Populations book from peoples of four continents: Africa, America, Asia and Oceania, where admixture and population stratification occurs in distinct patterns.

Ethnic specificity has become an integral part of research in the overlapping sciences of pharmacogenetics and pharmacogenomics. Pharmacogenomics in Admixed Populations was conceived to compile pharmacogenetic/-genomic (PGx) data from peoples of four continents: Africa, America, Asia and Oceania, where admixture and population stratification occursCited by: CHAPTER I I Pharmacogenetics in Admixed Polynesian Populations.

In book: Pharmacogenomics in Admixed Populations, Publisher: Landes Bioscience, Austin TX, pp Admixed populations. Trends Pharmacol Sci. Apr;26(4) Pharmacogenomics in admixed populations. Suarez-Kurtz G(1). Author information: (1)Division of Pharmacology, Instituto Nacional de Câncer, Rio de Janeiro, RJBrazil.

[email protected] Personalized drug therapy proffered by pharmacogenomics must be based on the recognition of inherent genetic individuality, rather than Cited by: Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time.

It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various. PHARMACOGENETICS IN ADMIXED POPULATIONS: Brazilas amodelcase PHARMACOGENETICS IN ADMIXED POPULATIONS: BrazilBrazil as aas a model case GuilhermeSuarez-Kurtz Suarez-Kurtz et al., Pharmacogenomics J, 20 40 60 80 0,0 0,2 0,4 0,6 0,8 1,0 Proportion of genetic ancestry E F G Concern over predictive pharmacogenomic tests might be extended to drug development because genetic differences in either admixed or homogenous populations might result in the preferential development of drugs that benefit one group more than gh central to the impact of pharmacogenomics on societies, this issue is outside mainstream drug research and development, Cited by:   This review focuses on warfarin pharmacogenomics in sub-Saharan peoples, African Americans and admixed Brazilians.

These ‘Black’ populations differ in several aspects, notably their extent of recent admixture with Europeans, a factor which impacts on the frequency distribution of pharmacogenomic polymorphisms relevant to warfarin dose Cited by: Pharmacogenomics in Admixed Populations Article Literature Review in Trends in Pharmacological Sciences 26(4) May with 17 Reads How we measure 'reads'Author: Guilherme Suarez-Kurtz.

Pharmacogenomics in Admixed Populations by G. Suarez-kurtz,available at Book Depository with free delivery worldwide. pharmacogenomics in sub-Saharan peoples, African Americans and admixed ‘Black’ populations differ in several aspects, notably their extent of recent admixture with Europeans, a factor which impacts on the frequency distribution ofCited by: Suarez-Kurtz G.

Pharmacogenomics in admixed populations. Trends Pharmacol Sci ; – PubMed; Crettol S, Petrovic N, Murray M. Pharmacogenetics of Phase I and Phase II Drug Metabolism. Curr Pharm Des ; – PubMed; Somogy A. Evolution of pharmacogenomics. Proc Western Pharmacol Soc ; 1–4.

PubMed. This review focuses on warfarin pharmacogenomics in sub‐Saharan peoples, African Americans and admixed Brazilians. These ‘Black’ populations differ in several aspects, notably their extent of recent admixture with Europeans, a factor which impacts on the frequency distribution of pharmacogenomic polymorphisms relevant to warfarin dose Cited by: Pharmacogenomics is the study of the role of the genome in drug response.

Its name (pharmaco-+ genomics) reflects its combining of pharmacology and cogenomics analyzes how the genetic makeup of an individual affects his/her response to drugs. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or.

Racial and ethnic differences in drug responses are now well studied and documented. Pharmacogenomics research seeks to unravel the genetic underpinnings of inter-individual variability with the aim of tailored-made theranostics and therapeutics.

Taking into account the differential expression of pharmacogenes coding for key metabolic enzymes and transporters that affect drug pharmacokinetics Cited by: The study of pharmacogenetics and pharmacogenomics focuses on how our genes and complex gene systems influence our response to drugs.

Recent progress in the science of clinical therapeutics has led to the discovery of new biomarkers that make it technically easier to identify groups of patients which are more or less likely to respond to individual therapies/5(2).

the 50 years since Kalow´s book was pub-lished, and was rechristened pharmaco-genomics (PGx) in the fashion of the ‘omics’ revolution, but its conceptual development and praxis remain contin-gent upon a better understanding of Pharmacogenomics in Admixed Populations.

Abstract “Pharmacogenetics deals with pharmacological responses and their mod-ification by hereditary influences.” 1 This definition, offered by Werner Kalow in the first book dedicated to pharmacogenetics (Kalow, ), highlights the three pillars of this discipline: pharmacology, genetics, and human by:   Book review; Services; Pharmacogenomics in Admixed Populations: Guilherme Suarez-Kurtz.

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Pharmacogenomics ← Pharmacogenomics in drug discovery and development _ QING YAN. Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives.

Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into.Title: Pharmacogenomics of Xenobiotic Metabolizing Enzymes in South American Populations VOLUME: 4 ISSUE: 1 Author(s):Mario B.

Filho, Rodolpho M. Albano, Ana Rossini and Luis F. R. Pinto Affiliation:Departamento de Bioquimica,Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado doRio de ard 28 de Setembro, 87, fundos, 4o andar, Vila Isabel,Rio de Janeiro, Cited by: 3.In this review we focus on the impact of genetic admixture on pharmacogenomics in the American continent, where five centuries of intermarriage between Amerindians, European and Africans, resulted in the extensive population heterogeneity observed nowadays.

especially when dealing with admixed populations. We conclude that a variable mosaic.